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Your Guide to Psilocybin-Assisted Therapy (Magic Mushrooms)

Join our free email report for the latest Psilocybin studies and research results, microdosing, to connect with therapists, clinics, and retreat centers, and learn more about Psilocybin’s potential benefits and therapeutic uses.

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DISCLAIMER/Harm Reduction: Psilocybin is a controlled substance, which is illegal in most jurisdictions. This site and its contents are for informational purposes only and are focused on the potential future of legal, licensed, clinical therapy, and in no way is intended to recommend or direct towards current use or obtaining illicit substances. Please read our full disclaimer.

It is important to understand that using any home-grown or street-bought Psilocybin or magic mushrooms ( aka “shrooms”) will not result in successful depression, anxiety, addiction or treatment of other mental illnesses because the Psilocybin therapy producing promising results in clinical trials is used along with specific, carefully crafted psychotherapy in a safe, controlled environment. Furthermore, Psilocybin purchased illicitly do not specify the precise amounts of Psilocybin, and may be adulterated with other, possibly harmful substances, making it impossible to dose properly for Psilocybin treatment or any kind of therapeutic purpose.

While there is no known lethal dose of mushrooms, taking too much Psilocybin or exercising while taking Psilocybin may lead to agitation, panic or paranoia, psychosis, seizures, or risk of coma.

At this time, and until medical use is legalized, anyone interested in Psilocybin-assisted therapy should focus solely on educating themselves through credible publications and scientific journals, and may inquire about potential legal clinical trials

Always consult with a licensed physician before beginning any therapy protocol, and be sure to know your jurisdiction's laws and regulations concerning such protocols.

Psilocybin Therapy or Microdosing

Some of the Conditions that May Be Treated:


Reported Increases in Wellbeing and Performance:


What is Psilocybin?

Is it the same as Shrooms, Magic Mushrooms, Boomers, Caps, Hongos or Mushies?

  • One of the most widely-used “classic” psychedelics, Psilocybin can be found in nearly 200 species of “magic mushrooms”. With its centuries-long history of use in spiritual, shamanic, and religious rituals, there is a rich history regarding the psychoactive effects.
  • The psilocybin these naturally occurring fungi produce have also been used in a therapeutic setting for several decades, with the purpose of treating conditions such as anxiety, depression, OCD, alcoholism and substance abuse disorders, PTSD, cluster headaches.
  • Effects typically include intensified thoughts, emotions, and sensory perception. At sufficiently high dosages psilocybin manifests primarily visual, as well as auditory, hallucinations.
  • Psilocybin-containing mushrooms go by nicknames and street names such as shrooms, boomers, caps, hongos and mushies.

Psilocybin Therapy Research & Legality

Psilocybin Therapy May Work as Well as Common Antidepressant
Scientific American, April 2021
  • In 2006, researchers at Johns Hopkins Center for Psychedelic and Consciousness Research published a landmark study covering the safety and positive effects of psilocybin. Today, dozens of clinical trials are underway or in the works.
At 2 months, the volunteers rated the psilocybin experience as having substantial personal meaning and spiritual significance and attributed to the experience sustained positive changes in attitudes and behavior consistent with changes rated by observers
  • A small study by Johns Hopkins Medicine researchers of Adults suffering from major depression, published in 2020, found that just two doses along with supportive psychotherapy resulted in rapid and significant reductions in their symptoms of depression.
The magnitude of the effect we saw was about four times larger than what clinical trials have shown for traditional antidepressants on the market
Alan Davis, adjunct assistant professor of psychiatry and behavioral sciences at the Johns Hopkins University School of Medicine.
  • Denver, Colorado became the first US city to decriminalize psilocybin in May 2019. The cities of Oakland and Santa Cruz, California, followed suit and decriminalized psilocybin in June 2019 and January 2020, respectively.In October 2020, Oregon became the first state to legalize psilocybin. Nationally, in the US decriminalization is gaining support. Internationally, laws vary considerably, although some countries such as Brazil have few, if any, instances of arrest or prosecution for possession or cultivation of psilocybin mushrooms.

How Does Treatment Work? Is it Safe?

  • Typically, there is a preparation phase in which the patient and therapist get to know one another, and form a trusting relationship.
  • During the session, the patient lies down in a specially designed room, with a comfortable bed or mat. They should feel at ease in the environment
  • Often, a specially curated music playlist will be listened to which is designed to heighten the inward journey, while wearing a comfortable eye mask, similar to one for sleeping.
  • Most patients begin to feel the significant effects approximately 30-45 minutes after receiving their dose, which typically lasts for 3-4 hours, followed by 1-2 hours of “come down”. A trained therapist remains present at all times throughout this session.
  • Following this time, sometimes referred to as a “journey”, patients are encouraged to discuss their experience. With guidance from their therapist, the goal is to identify insights that may create lasting positive change with emotional or behavioral patterns.

Benefits of Microdosing Psilocybin

Potential for reduction in the frequency and intensity of undesirable states, often related to mental illness or disorders, including:

  • Addiction / Alcohol Use Disorder
  • ADD / ADHD
  • Anxiety
  • Depression
  • Mood disorders
  • Post-Traumatic Stress Disorder (PTSD)

Potential for increase in the frequency and intensity of desirable states and outcomes, including:

  • Athletic Coordination
  • Clarity
  • Creativity
  • Energy
  • Flow State
  • Focus
  • Empathy and Improved Relationships
  • Leadership Performance

Clinical Study Roadmap

Psilocybin studies are in-progress or upcoming, relating to treatment for the following diseases, conditions, or symptoms:

  • Psilocybin Treatment of Major Depressive Disorder With Co-occurring Alcohol Use Disorder

  • Safety and Efficacy of Psilocybin for Body Dysmorphic Disorder

  • The Effect of Psilocybin on MDD Symptom Severity and Synaptic Density

  • Study of Psilocybin Enhanced Group Psychotherapy in Patients With Cancer

  • Exploring the Safety, Tolerability, and Preliminary Efficacy of Psychedelic-Assisted Psychotherapy for Anorexia

  • Psilocybin for the Treatment of Cluster Headache

  • Psilocybin for Depression in People With Mild Cognitive Impairment or Early Alzheimer's Disease

  • Psilocybin-facilitated Smoking Cessation Treatment

...and dozens more